| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6114849 | Current Opinion in Immunology | 2016 | 9 Pages |
Abstract
The isolation of HIV-1 broadly neutralizing antibodies (bnAbs) has demonstrated the ability of the human immune system to mount effective antibody responses against the virus. To harness this immune potential to elicit similar antibody responses by vaccination, it is important to understand the immunological processes that produce them. Here we review recent advances in crystal structural determinations of HIV-1 bnAb epitopes that directly portray the antigenic landscape of the HIV-1 envelope glycoprotein. We also summarize new immunological concepts implicated in bnAb sequences and their lineage studies.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Xueling Wu, Xiang-Peng Kong,