| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115075 | Current Opinion in Immunology | 2013 | 5 Pages |
Abstract
- TNF and its receptor, TNFR1, help orchestrate an inflammatory response to pathogens.
- TNFR1 signaling is therefore a frequent target of pathogen manipulation.
- We describe how the TNFR1 signaling pathway is targeted by pathogen virulence factors and how the different arms of TNFR1 signaling react.
- We examine recent data showing the importance of other members of the Death Receptor family in the immune response to pathogens.
- We discuss how understanding pathogen inhibition suggests clinical applications.
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Authors
John Silke, Elizabeth L Hartland,