Molecular determinants of sterile inflammation

- Sterile necrotic cell death induces acute inflammatory response.
- Macrophages sense the danger signals from dead cells and induce IL-1α.
- IL-1α also serves as a primary danger signal from dead cells in cell type specific manner.
- The neutrophilic inflammation to sterile necrotic cell death depends on both IL-1α and IL-1β.
- NLRP3 inflammasome senses intracellular changes indicative of cellular damage.