| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115168 | Current Opinion in Immunology | 2012 | 6 Pages |
Abstract
⺠The aging immune system is more prone to inflammation but less protective. ⺠DNA damage reduces stem cell renewal, depleting lymphoid and promoting myeloid progenitors. ⺠Poor DNA repair perpetuates damage and alters mature lymphocyte function. ⺠Aged T and B lymphocytes are less antigen-dependent and more inflammatory. ⺠Cytokine production by senescent cells exacerbates inflammation.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Mary M Cavanagh, Cornelia M Weyand, Jörg J Goronzy,