Article ID Journal Published Year Pages File Type
6115170 Current Opinion in Immunology 2012 7 Pages PDF
Abstract
► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age - the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vaccine can restore this immunity and prevent herpes zoster. ► Suggestions are offered to improve the efficacy of zoster vaccine.
Related Topics
Life Sciences Immunology and Microbiology Immunology
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