| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115178 | Current Opinion in Immunology | 2009 | 7 Pages |
Abstract
Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.
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Authors
Cordula Kemp, Jean-Luc Imler,