| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115212 | Current Opinion in Immunology | 2012 | 8 Pages |
Abstract
⺠IgA, by promoting microbial diversity in the gut, is likely to have played a fundamental role in mammalian evolution. ⺠The IgA system fulfils multiple functions in order to maintain homeostasis at mucosal surface. ⺠IgA regulates the intestinal microbiota that is pivotal for efficient immune system and metabolic function. ⺠Defects in IgA regulation have the potential to increase autoimmune susceptibility beyond mucosal surfaces.
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Authors
Duncan B Sutherland, Sidonia Fagarasan,