| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115226 | Current Opinion in Immunology | 2012 | 6 Pages |
Abstract
⺠The advantages and disadvantages of recombinant bacterial vaccines are discussed with relevant examples. ⺠Recombinant subunit vaccines are safer but have a demanding manufacturing process. ⺠Recombinant whole cell vaccines demonstrate better immunogenicity but represent a regulatory challenge due the safety concerns. ⺠Recombinant bacterial carriers are being developed for delivery of vaccines toward infectious as well as metabolic diseases. ⺠New approaches like structural vaccinology are key in vaccine design against antigens that are highly variable.
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Authors
Meera Unnikrishnan, Rino Rappuoli, Davide Serruto,