Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

► Autophagy is a developing immunological paradigm with vertical and lateral connections in innate immunity. ► Sequestosome 1/p62-like adaptors (SLRs) serve both as autophagic adaptors and innate immunity signaling platforms. ► Balance between autophagic clearance via SLRs and their and other inflammatory signaling determines degree of collateral inflammatory damage. ► Interactions between autophagy and inflammasome involve both suppression of inflammasome activation and enhancement through the autophagy-based unconventional secretion of inflammasome substrates.