| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115243 | Current Opinion in Immunology | 2012 | 9 Pages |
Abstract
⺠ITAM-containing immunoreceptors couple with several classes of heterologous receptors to initiate context-specific cellular functions. ⺠The logic of coupling the ITAM-module with the heterologous receptors is currently unclear. ⺠Heterologous receptors that do not contain ITAM motifs may directly engage ITAM adapters in their signaling pathway. ⺠Alternatively, they may indirectly access ITAM-supported functions by coupling to a relevant immunoreceptor. ⺠New concepts postulate how heterologous receptors collaborate to create unique signals by using a limited set of conserved signaling module.
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Authors
Jelena S Bezbradica, Ruslan Medzhitov,