| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115251 | Current Opinion in Immunology | 2012 | 6 Pages |
Abstract
⺠Self-peptides-MHC complexes expressed by thymic stromal cells direct T cell selection. ⺠Cortical epithelial cells are involved in positive selection. ⺠Medullary epithelial cells and dendritic cells drive thymic negative selection. ⺠These three cell types use various processes and enzymes to generate self-peptides. ⺠Thymic stromal cell subsets may present distinct sets of self-peptides-MHC complexes.
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Authors
Sylvie Guerder, Christophe Viret, Hervé Luche, Laurence Ardouin, Bernard Malissen,