| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115265 | Current Opinion in Immunology | 2013 | 7 Pages |
Abstract
⺠PLZF is the master transcription factor of the NKT cell lineage. ⺠PLZF is induced during thymic development by Egr2 downstream of TCR/NFAT signaling. ⺠PLZF directs acquisition of the innate-like effector program whereas Egr2 and other TCR signals/cosignals induce cell division. ⺠In addition to the major T-bethigh NKT1 subset, novel NKT sublineages include NKT2 and NKT17. ⺠Different mouse strains exhibit wide variations in the relative representation of NKT1, NKT2 and NKT17.
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Authors
Michael G Constantinides, Albert Bendelac,