| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115274 | Current Opinion in Immunology | 2013 | 8 Pages |
Abstract
⺠Galectin-1 (Gal-1) is commonly expressed at a high level by tumor cells and causes immune suppression of antitumor T cells. ⺠Gal-1-Gal-1-binding carbohydrate interactions play a pivotal role in shaping the effector function of antitumor T cells. ⺠Gal-1-binding carbohydrates, known as N-acetyllactosaminyl glycans, are targetable entities on antitumor T cells. ⺠Fluorinated glucosamine analogs are effective metabolic inhibitors of N-acetyllactosamine formation. ⺠Glucosamine analogs are effective agents for thwarting Gal-1-mediated immune suppression of effector anti-tumor T cells.
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Authors
Charles J Dimitroff,