| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115332 | Current Opinion in Immunology | 2012 | 6 Pages |
Abstract
⺠Genetic susceptibility to T1D is a composite of risk factors contributed by the major histocompatibility complex with a large number of additional genetic modifiers. ⺠The functional properties of each of these susceptibility genes vary owing to subtle genetic variation that occurs normally in the population. ⺠Identification of functional pathways impacted by specific GWAS 'hits' link disease progression to distinct steps in immune activation, expansion, and regulation. ⺠Stratification of risk based on genetic variation provides a classification scheme that implicates distinct functional pathways as therapeutic targets.
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Authors
Gerald T Nepom, Jane H Buckner,