| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115333 | Current Opinion in Immunology | 2012 | 8 Pages |
Abstract
⺠Genetic studies of inflammatory bowel disease have identified multiple risk loci that contain autophagy genes. ⺠Autophagy-related genes implicated in IBD play roles in xenophagy, vesicular trafficking/secretion, and cytokine secretion. ⺠Defects in xenophagy may cause impaired bacterial handling and promote inappropriate host responses to commensal organisms. ⺠Multiple Crohn's disease-associated polymorphisms may converge on Paneth cell phenotypes and function.
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Authors
Agnès Gardet, Ramnik J Xavier,