| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115347 | Current Opinion in Immunology | 2012 | 11 Pages |
Abstract
⺠The retroviral toolbox for lymphocyte modification is constantly expanding. ⺠Challenges associated with retrovirus-cell interactions still need to be addressed. ⺠Envelope modifications support the transduction of resting lymphocytes by lentiviral vectors. ⺠Modifications to the integration pattern and transgene design address the risk of insertional mutagenesis. ⺠Further modifications in cargo design, often using synthetic bricks, may increase potency and safety.
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Authors
Julia D Suerth, Axel Schambach, Christopher Baum,