| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115349 | Current Opinion in Immunology | 2012 | 8 Pages |
Abstract
⺠Homologous recombination is a safe and effective strategy for gene therapy. ⺠Engineered nucleases increase gene targeting for PID genes in human cells. ⺠Gene targeting can correct mutations or insert transgenes into specific loci. ⺠Nuclease efficacy can be hampered by toxicity and chromatin configuration.
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Authors
Stacey E Wirt, Matthew H Porteus,