| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115350 | Current Opinion in Immunology | 2012 | 8 Pages |
Abstract
⺠Induced pluripotent stem cells (iPSCs) may provide a renewable stem cell source for use in research. ⺠Patient-derived iPSCs are a valuable platform for primary immunodeficiency disease modeling and correction. ⺠Robust in vitro hematopoietic differentiation protocols are key to study the molecular mechanisms underlying immune manifestations of PID. ⺠Human T lineage development can be modeled using the iPSC/OP-9DL system. ⺠Safety measures need to be in place before translating iPSC technology into the clinical arena.
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Authors
Katja G Weinacht, Patrick M Brauer, Kerstin Felgentreff, Alex Devine, Andrew R Gennery, Silvia Giliani, Waleed Al-Herz, Axel Schambach, Juan Carlos Zúñiga-Pflücker, Luigi D Notarangelo,