| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6115366 | Current Opinion in Immunology | 2011 | 11 Pages |
Abstract
The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.
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Authors
Finlay W McNab, Ricardo Rajsbaum, Jonathan P Stoye, Anne O'Garra,