Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6115889 | Diagnostic Microbiology and Infectious Disease | 2014 | 12 Pages |
Abstract
The KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) is an important pathogen widely spread in nosocomial infections. In this study, we identified the KPC-2-producing K. pneumoniae clinical isolates of 2 unrelated outbreaks that corresponded to pandemic strain ST258. The isolates showed high resistance to cephalosporins, carbapenems, quinolones, and colistin. The KPC-2-producing K. pneumoniae isolates were compared to the previously studied KPC-3-producing K. pneumoniae isolates from an outbreak in Mexico; they showed an unrelated pulsed-field gel electrophoresis fingerprinting pattern and a different plasmid profile. The KPC-2 carbapenemase gene was identified in two 230- and 270-kb non-conjugative plasmids; however, 1 isolate transferred the KPC-2 gene onto an 80-kb plasmid. These findings endorse the need of carrying out a continuous molecular epidemiological surveillance of carbapenem-resistant isolates in hospitals in Mexico.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Ulises Garza-Ramos, Humberto Barrios, Fernando Reyna-Flores, Alejandro Sánchez-Pérez, Elsa Tamayo-Legorreta, Alvaro Ibarra-Pacheco, Juana Salazar-Salinas, Ricardo Núñez-Ceballos, Jesus Silva-Sanchez,