| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6116708 | Human Immunology | 2014 | 7 Pages |
Abstract
B7-H4 is overexpressed in human cervical cancers, and it is associated with lower numbers of tumor-infiltrating CD8+T lymphocytes and therefore less IFN-γ production. In vitro, B7-H4 inhibits the proliferation of CD4+T and CD8+T but promotes the proliferation of Tregs and the secretion of IL-10 and TGF-β1. B7-H4 plays an important role in depressing the anti-tumor immunity of CD8+T cell in microenvironments of cervical cancer.
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Authors
Xin Wang, Tingting Wang, Man Xu, Ling Xiao, Yi Luo, Wenlian Huang, Yan Zhang, Weipu Geng,