IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation

Article ID	Journal	Published Year	Pages	File Type
6116991	Immunology Letters	2016	11 Pages	PDF

Abstract

The anti-arthritis effects of hIL-1RA-Fc are associated with regulation of balance between Th17 cells and Treg cells and suppression of osteoclastogenesis and angiogenesis in the affected joints.

Keywords

MLR HIF APC Treg Th17 DMARD JIA i.p.TRAP ACR IFA RANKL HRP CII RORγt intradermally PerCP PBMC CTLA-4 EULAR mAb FOXP3 FITC TGF-β the European League Against Rheumatism PBS type 17 helper T cell incomplete Freund’s adjuvant Autoimmune arthritis collagen induced arthritis Juvenile idiopathic arthritis Rheumatoid arthritis allophycocyanin STAT IL-1 receptor antagonist Monoclonal antibody cytotoxic T-lymphocyte antigen 4 Angiogenesis Osteoclastogenesis tartrate-resistant acid phosphatase immunoglobulin interleukin Enzyme-linked immunosorbent assay ELISA cluster of differentiation Intraperitoneally Disease-modifying antirheumatic drug Rank Regulatory T cell Peripheral blood mononuclear cell Th17 cells Regulatory T cells CIA i.d.Hypoxia-inducible factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)TNF-α phycoerythrin Phosphate buffered saline fluorescein isothiocyanate Signal transducer and activator of transcription polymerase chain reaction PCR mixed leukocyte reaction Horseradish peroxidase American College of Rheumatology Type II collagen

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IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation

Authors

Seon-Yeong Lee, Hong Ki Min, Seung Hoon Lee, Hye Jeong Shin, Woon Young Lee, Young-Gyu Cho, Seung-Ki Kwok, Ji Hyeon Ju, Mi-La Cho, Sung-Hwan Park,