Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6117240 | Immunology Letters | 2014 | 10 Pages |
Abstract
The adaptive immune system consists of T and B cells that express clonally distributed antigen receptors. To achieve functional adaptive immune responses, antigen-specific T cell populations are stimulated by professional antigen-presenting cells like dendritic cells (DCs), which provide crucial stimulatory signals for efficient expansion and development of effector functions. Antigen-specific B cells receive costimulatory signals from helper T cells to stimulate affinity maturation and isotype switching. Here we elaborate on the interactions between DCs, T cells and B cells, and on the important signals for efficient induction of adaptive immune responses.
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Authors
Joke M.M. den Haan, Ramon Arens, Menno C. van Zelm,