PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease

These results show significantly lower PON1 activity associated with HDL-C in TA patients, this activity could be depending on PON1 genotypes; showing that QR/LM/CT has the lowest hydrolytic activity toward paraoxon meanwhile, PON1192,55,−108 genetic variations are related with reduced PON1 activities, these could be factors contributing to the development of TA disease.