| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117322 | Immunology Letters | 2013 | 5 Pages |
Abstract
⺠Tumor cells evade the immune system by upregulating coinhibitory molecules. ⺠Upregulation of coinhibitory molecules such as PD1 attenuates T-cell anti-tumor response. ⺠Blockade of PD1/PDL1 reverses T cell suppressor and tumor protective mechanisms. ⺠Clinical trials with antagonist PD1/PDL1 mAbs are ongoing in advanced diseases. ⺠We propose the inhibitory molecule BTLA and its ligand HVEM as new targets.
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Authors
Christine Pasero, Daniel Olive,