IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood

Article ID	Journal	Published Year	Pages	File Type
6117363	Immunology Letters	2011	9 Pages	PDF

Abstract

âº IL-15 can induce the proliferation of Tregs in the presence of dendritic cells (DCs). âº The induction is mediated by DCs presenting IL-15 in trans to Tregs. âº Tregs may proliferate in the absence of IL-2 in vivo.

Keywords

CPC 3H-TdR PI3K PBMC Tregs IL-15 CPM GM-CSF ERK APC MAPK STAT Akt interleukin Proliferation Teff Peripheral blood mononuclear cell Dendritic cell CD4+CD25+ regulatory T cells Dendritic cells Regulatory T cells antigen presenting cell counts per minute phosphoinositol-3-kinase Signal transducer and activator of transcription protein kinase B mitogen-activated protein kinase extracellular signal-regulated kinase

Related Topics

Life Sciences Immunology and Microbiology Immunology

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IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood

Authors

Shuxiong Xu, Zhaolin Sun, Yan Sun, Jianguo Zhu, Xiaowei Li, Xinqi Zhang, Gang Shan, Zhenxing Wang, Hong Liu, Xiongfei Wu,