Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms

Article ID	Journal	Published Year	Pages	File Type
6117385	Immunology Letters	2012	9 Pages	PDF

Abstract

âº Two ELISAs measuring the same antigen give different results. âº Different domains of the protein are recognized. âº Different soluble forms exits in cancer patients and explain these results.

Keywords

autoantibodies EpCAM enzyme linked immunosorbent assay Colon cancer Tumor marker

Related Topics

Life Sciences Immunology and Microbiology Immunology

Preview

Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms

Authors

Oliver Schmetzer, Gerhard Moldenhauer, Annett Nicolaou, Peter Schlag, Rainer Riesenberg, Antonio Pezzutto,