| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117400 | Immunology Letters | 2012 | 8 Pages |
Abstract
⺠Mesenchymal stem cell-derived microvesicles (MVs) were found to be potent mediators to shed peripheral tolerance towards EAE mice auto-reactive T cells via bearing of tolerogenic molecules. ⺠Additionally, inducing inflammatory setting on MSCs, revealed the enhancing regulatory effects of MVs via increased expression of some regulatory molecules, specifically PD-L1 and TGF-β. ⺠Induction of tolerogenic signaling, promotion of CD4+ CD25+ Foxp3+ regulatory T cells generation and apoptotic activity towards activated T cells are shown to be main possible mechanisms involved in MVs-mediated regulation.
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Authors
Aram Mokarizadeh, Nowruz Delirezh, Ahmad Morshedi, Ghasem Mosayebi, Amir-Abbas Farshid, Karim Mardani,