| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117419 | Immunology Letters | 2011 | 10 Pages |
Abstract
⺠We examined PGE2 enhancement of antigen-mediated degranulation in human mast cells. ⺠Cells from only half of donors responded to PGE2. ⺠The differences in responses were not due to differences in receptor expression. ⺠The differences reflect defective enhancement of calcium flux in non-responders. ⺠Results may have relevance to role of co-activating receptors in allergic disorders.
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Authors
Hye Sun Kuehn, Mi-Yeon Jung, Michael A. Beaven, Dean D. Metcalfe, Alasdair M. Gilfillan,