Myeloid differentiation protein 2 silencing decreases LPS-induced cytokine production and TLR4/MyD88 pathway activity in alveolar macrophages

Article ID	Journal	Published Year	Pages	File Type
6117425	Immunology Letters	2011	8 Pages	PDF

Abstract

âº RNA interference of MD-2 attenuated LPS-induced up-regulated transcription levels of MD-2, TLR4 and MyD88 in the NR8383 cell line. âº LPS induced increases of TNF-(alpha), IL-1Î² and IL-6 levels in NR8383 cell supernatants was inhibited by MD-2 silencing. âº In association with TLR4/MyD88 pathway MD-2 silencing may be a potential therapeutic tool against LPS-induced lung inflammation.

Keywords

LPS MYD88 AMS TLR4 MD-2 myeloid differentiation protein small interfering RNAs siRNA Acute lung injury Ali lipopolysaccharide Lipopolysaccharide (LPS)Alveolar macrophages myeloid differentiation protein 2 Toll-like receptor 4