| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117429 | Immunology Letters | 2011 | 7 Pages |
Abstract
⺠Overexpression of CD200transgene increases allogeneic skin graft survival. ⺠Both graft tissue and draining lymph nodes show increased infiltration of Foxp3+ Treg. ⺠Gene expression profiling confirms increased expression of Treg-associated genes, as well as increased expression of genes encoding CCR4 and ligands, CCL17/22. ⺠Suppression of CCR4 expression with lentivirus encoding shRNA blocks Foxp3 Treg infiltration and increased skin graft survival.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Kai Yu, Zhiqi Chen, Ismat Khatri, Reginald M. Gorczynski,