Article ID Journal Published Year Pages File Type
6117431 Immunology Letters 2011 11 Pages PDF
Abstract
► The recombinant P22 protein is a protective antigen against schistosomiasis in mice. ► rP22 is a tegument protein localized on the surface of S. mansoni adult worms. ► Mice immunization with rP22 induced a reduction in worm burden and in hepatic eggs. ► rP22 vaccination also induced a significant reduction in liver granuloma size. ► Protection was associated with elevated production of IFN-γ, TNF-α, and IL-10.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Immunization with rP22 induces protective immunity against Schistosoma mansoni: Effects on granuloma down-modulation and cytokine production
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