| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117459 | Immunology Letters | 2011 | 10 Pages |
Abstract
⺠MCS-18, a natural product isolated from the plant Helleborus purpurascens increases diabetes free survival using the NOD-mouse model. ⺠MCS-18 treatment significantly reduces islet T-cell infiltrates as well as the rate of T-cell proliferation. ⺠Periinsular infiltrates in the MCS-18 treated animals show an enhanced number of Foxp3+ CD25+ regulatory T cells. ⺠MCS-18 exerts an efficient immunosuppressive activity.
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Authors
Christian Seifarth, Leonie Littmann, Yazid Resheq, Susanne Rössner, Andreas Goldwich, Nadine Pangratz, Franz Kerek, Alexander Steinkasserer, Elisabeth Zinser,