| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6117461 | Immunology Letters | 2011 | 7 Pages |
Abstract
⺠A single chain human antibody (scFv) was selected by bio-panning of a phage-display library. ⺠The clones were selected for their capacity to recognize toxin Ts1 from the scorpion Tityus serrulatus. ⺠Clone 15e was capable of recognizing and partially protecting mice from the toxic effect of Ts1. ⺠The single chain antibody (scFv) was VH6-VK4, containing 124 amino acids for VH6 and 114 for VK4. ⺠The clone 15e also recognizes toxins from other species of dangerous scorpions of the same genus from the Amazonic region. ⺠It is a leading compound for the development of neutralizing antibodies of human origin against scorpion stings in South American countries.
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Authors
Itzel Amaro, Lidia Riaño-Umbarila, Baltazar Becerril, Lourival D. Possani,