Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6117546 | Immunology Letters | 2008 | 7 Pages |
Abstract
Soluble forms of CD83, a dendritic cell-specific surface glycoprotein, have been strongly proposed to be of therapeutic utility in inflammatory conditions such as multiple sclerosis and transplantation. We demonstrate here, however, that eukaryotically expressed, recombinant soluble human CD83-Ig molecules fail to achieve efficacy in model systems for those conditions: mouse experimental autoimmune encephalomyelitis models in vivo or in mixed lymphocyte reactions in vitro. These results raise concern as to the viability of a eukaryotically expressed soluble CD83 strategy for clinical therapeutic use.
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Authors
Achal Pashine, Ulrich Göpfert, Jinzhi Chen, Eike Hoffmann, Paul S. Dietrich, Stanford L. Peng,