Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6117944 | International Journal of Antimicrobial Agents | 2013 | 5 Pages |
Abstract
New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation as well as their control system, the quorum-sensing (QS) system, a mechanism of communication used to co-ordinate bacterial activities. Here we describe the evaluation of synthetic organic compounds as bacterial biofilm inhibitors against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. This approach has successfully allowed the identification of five compounds (GEt, GHex, GOctad, G19 and C33) active not only against bacterial biofilms but also displaying potential to be used as antagonists and/or inhibitors of bacterial QS.
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Authors
Andréa de Lima Pimenta, Louise Domeneghini Chiaradia-Delatorre, Alessandra Mascarello, Karen Andrinéia de Oliveira, Paulo César Leal, Rosendo Augusto Yunes, Cláudia Beatriz Nedel Mendes de Aguiar, Carla Inês Tasca, Ricado José Nunes, Artur Jr.,