Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6118044 | International Journal of Antimicrobial Agents | 2013 | 4 Pages |
Abstract
Treatment results of six post-neurosurgical ventriculitis and meningitis cases caused by extensively drug-resistant Acinetobacter baumannii after application of an intraventricular loading dose of 500Â 000 IU (40Â mg) of colistin followed by a dose of 125Â 000-250Â 000 IU (10-20Â mg) every 24-48Â h plus parenteral colistin are reported. Simultaneous bacteraemia with an identical Acinetobacter strain was observed in three patients. The mean duration of treatment was 17.2 days (range 15-21 days) and the median time of sterilisation of cerebrospinal fluid was 2.5 days (range 1-5 days). All patients were cured, however one patient presented with chemical meningitis and one with chemical ventriculitis, conditions that clinically and biochemically resemble bacterial meningitis.
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Authors
Ilias Karaiskos, Lambrini Galani, Fotini Baziaka, Emmanouela Katsouda, Ioannis Ioannidis, Alexandros Andreou, Harry Paskalis, Helen Giamarellou,