| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6118488 | International Journal of Antimicrobial Agents | 2011 | 6 Pages |
Abstract
The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.
Keywords
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Applied Microbiology and Biotechnology
Authors
V. Kuete, S. Alibert-Franco, K.O. Eyong, B. Ngameni, G.N. Folefoc, J.R. Nguemeving, J.G. Tangmouo, G.W. Fotso, J. Komguem, B.M.W. Ouahouo, J.-M. Bolla, J. Chevalier, B.T. Ngadjui, A.E. Nkengfack, J.-M. Pagès,