Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119248 | Journal of Autoimmunity | 2015 | 10 Pages |
Abstract
Our findings indicate that CD patients possess T cells capable of responding to immuno-dominant hordein epitopes and homologous avenin peptides ex vivo, but the frequency and consistency of these T cells in blood is substantially higher after oral challenge with barley compared to oats. The low rates of T cell activation after a substantial oats challenge (100 g/d) suggests that doses of oats commonly consumed are insufficient to cause clinical relapse, and supports the safety of oats demonstrated in long-term feeding studies.
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Authors
Melinda Y. Hardy, Jason A. Tye-Din, Jessica A. Stewart, Frederike Schmitz, Nadine L. Dudek, Iresha Hanchapola, Anthony W. Purcell, Robert P. Anderson,