| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119286 | Journal of Autoimmunity | 2014 | 8 Pages |
Abstract
We also show that TNF itself induces sXBP1 in SF, thus generating a potential feedback loop for sustained SF activation. These data confirm the first link between TLR-dependent XBP1 activation and human inflammatory disease. sXBP1 appears to play a central role in this process by providing a convergence point for two different stimuli to maintain activation of SF.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Sinisa Savic, Lylia Ouboussad, Laura J. Dickie, Janina Geiler, Chi Wong, Gina M. Doody, Sarah M. Churchman, Frederique Ponchel, Paul Emery, Graham P. Cook, Maya H. Buch, Reuben M. Tooze, Michael F. McDermott,