Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119332 | Journal of Autoimmunity | 2013 | 6 Pages |
Abstract
We previously identified a subset of anti-DNA antibodies that binds the N-methyl-d-aspartate receptor. We now show that both mouse and human anti-DNA antibodies with this specificity bind C1q. These antibodies bind to Clq in glomeruli and exhibit decreased glomerular deposition in the absence of C1q. We propose that this subset of anti-DNA antibodies participates in lupus pathogenesis through direct targeting of C1q on glomeruli and also through removal of soluble C1q thereby limiting the ability of C1q to mediate immune homeostasis.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Giovanni Franchin, Myoungsun Son, Sun Jung Kim, Ilan Ben-Zvi, Jie Zhang, Betty Diamond,