Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119346 | Journal of Autoimmunity | 2012 | 13 Pages |
Abstract
⺠We defined the probability of links between environmental factors and autoimmunity. ⺠Innate immunity mediated by toll-like receptors mediates tolerance breakdown. ⺠Abnormalities in B, Th17, and T regulatory cells lead to autoimmunity. ⺠Self antigens undergo post-translational modifications causing molecular mimicry. ⺠Epigenetic changes, not limited to DNA methylation, may predispose to autoimmunity. ⺠Mechanisms are in agreement with epidemiology and models discussed in the issue.
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Authors
Carlo Selmi, Patrick S.C. Leung, David H. Sherr, Marilyn Diaz, Jennifer F. Nyland, Marc Monestier, Noel R. Rose, M.Eric. Gershwin,