Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus

► Apoptosis resulting from co-ligation of the BCR and FcγRIIB is caspase 8-dependent. ► Such apoptosis is associated with mitochondrial and lysosomal disruption. ► Apoptosis resulting from co-ligation of the BCR and FcγRIIB is associated with Fas signalling. ► Apoptosis resulting from co-ligation of the BCR and FcγRIIB is defective in the MRL/Lpr model of SLE.