Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119363 | Journal of Autoimmunity | 2012 | 10 Pages |
Abstract
⺠Deficiency of the Th2 transcription factor STAT6 can promote atopy and autoimmunity. ⺠Loss of STAT6 markedly exacerbates autoimmune disease in Lynâ/â mice. ⺠Aged Lynâ/âSTAT6â/â mice produce autoreactive IgE. ⺠Older Lynâ/âSTAT6â/â mice have dramatically increased IgE but minimal IgG1. ⺠STAT6-independent factors can promote IgE class-switching in the absence of IgG1.
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Authors
Maverick Lau, Evelyn Tsantikos, Mhairi J. Maxwell, David M. Tarlinton, Gary P. Anderson, Margaret L. Hibbs,