| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119382 | Journal of Autoimmunity | 2012 | 10 Pages |
Abstract
⺠MicroRNA are required to potentiate T cell activation and Th1 effector expansion. ⺠Excision of Dicer results in profound inhibition of T cell activation. ⺠The anti-autoimmune function of T cell microRNA is restricted to pathology of the colon. ⺠A pro-autoimmune function of T cell microRNA is observed systemically. ⺠Reduction of Dicer within T cells has the potential to mitigate Th1 autoimmunity.
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Authors
Lei Tian, Gert De Hertogh, Maya Fedeli, Kim A. Staats, Susann Schonefeldt, Stephanie Humblet-Baron, Ludo Van Den Bosch, Paolo Dellabona, James Dooley, Adrian Liston,