| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119397 | Journal of Autoimmunity | 2012 | 9 Pages |
Abstract
⺠We examined how genes, environment, and hormones influence female lupus susceptibility. ⺠Environmental agents suppress ERK signaling, epigenetically activating immune genes. ⺠Transgenic female but not male mice with an inducible ERK defect developed lupus. ⺠Suppressing ERK epigenetically activated X-chromosome CD40L and kirl1 genes in females. ⺠Female predisposition required estrogen, two X chromosomes and ERK suppression.
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Authors
Faith M. Strickland, Anura Hewagama, Qianjian Lu, Ailing Wu, Robert Hinderer, Ryan Webb, Kent Johnson, Amr H. Sawalha, Colin Delaney, Raymond Yung, Bruce C. Richardson,