| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119398 | Journal of Autoimmunity | 2012 | 12 Pages |
Abstract
⺠Gender-based transcriptomics uncovers distinct changes in gene expression in women and men with MS. ⺠MS is associated with alterations in the quantity and in the quality of the human sex-specific genes. ⺠Female and male MS gene profiles share biological processes and interactomes. ⺠Female and male MS gene profiles are under the control of the transcription factor SP1. ⺠Blockade of SP1 dependent gene transcription ameliorates EAE.
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Authors
Ramesh Menon, Marco Di Dario, Chiara Cordiglieri, Silvia Musio, Loredana La Mantia, Clara Milanese, Anna Luisa Di Stefano, Massimo Crabbio, Diego Franciotta, Roberto Bergamaschi, Rosetta Pedotti, Enzo Medico, Cinthia Farina,