| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119402 | Journal of Autoimmunity | 2012 | 6 Pages |
Abstract
⺠The X chromosome contains the largest number of immune-related genes of human genome. ⺠X chromosome defects may explain the female preponderance in autoimmune diseases. ⺠High number of X monosomy cells was found in women with autoimmune diseases. ⺠X-linked genes dosage may play a role in loss of tolerance. ⺠X-linked microRNAs may be involved in development of autoimmune diseases.
Keywords
Female preponderanceXCIPIDSSCX-linked hyper-IgM syndromeIPEXHIGMAITDPBCEtiopathogenesissystemic sclerosisWASautoimmune thyroid diseaseAutoimmune diseasesautoimmunityWiskott-Aldrich syndromePrimary biliary cirrhosisGenetic factorsX chromosome inactivationSystemic lupus erythematosusSLEmajor histocompatibility complexMHCGenome-wide association studyGWASSex chromosomesAID
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Authors
Ilaria Bianchi, Ana Lleo, M. Eric Gershwin, Pietro Invernizzi,