| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6121815 | Journal of Hospital Infection | 2016 | 4 Pages |
Abstract
The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
D. Hungerford, J.M. Read, R.P.D. Cooke, R. Vivancos, M. Iturriza-Gómara, D.J. Allen, N. French, N. Cunliffe,