| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6122585 | Journal of Infection | 2016 | 33 Pages |
Abstract
This review article identified ten major features associated with immunosuppression and immunological dysregulation in sepsis. Assessment of these features could help in utilizing precision medicine for the treatment of sepsis with immuno-modulatory drugs.
Keywords
HLA-DRTα1neutrophil serine proteasesThymosin alpha-1sTNF-RSTAT5granulocyte-macrophage colony stimulating factorTregsTregGM-CSFIFN-γNSPCNCPD-L1PD-1mRNANETsmessenger RNADysfunctionAntigen presentationImmunologicalimmunoglobulinsinterleukinneutrophil extracellular trapsT regulatory cellNK cellsNatural killer cellsSepsisGranulocyte-colony stimulating factorG-CSFTNF-αsignal transducer and activator of transcription 5Complementprogrammed death-ligand 1Neutrophilspolymerase chain reactionPCRInterferon gammasoluble TNF receptor
Related Topics
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Authors
Jesús F. Bermejo-Martin, David Andaluz-Ojeda, Raquel Almansa, Francisco GandÃa, Jose Ignacio Gómez-Herreras, Esther Gomez-Sanchez, MarÃa Heredia-RodrÃguez, Jose Maria Eiros, David J. Kelvin, Eduardo Tamayo,